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Article

Candidiasis in patients with APS-1: low IL-17, high IFN-γ, or both?

Current opinion in immunology - 1 Oct 2021

Philippot Quentin, Casanova Jean-Laurent, Puel Anne

Abstract excerpt

Chronic mucocutaneous candidiasis (CMC) is one of the earliest and most frequent clinical manifestations of autosomal recessive autoimmune polyendocrine syndrome type 1 (APS-1), a monogenic inborn error of immunity caused by deleterious variants of the autoimmune regulator (AIRE) gene. APS-1 patients suffer from various autoimmune diseases, due to the defective thymic deletion of autoreactive T cells, and the...

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Identifiers

PMID: 34455138
DOI: 10.1016/j.coi.2021.08.001
PMCID: PMC9359210

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