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Article

Functions of the Thyroid-Stimulating Hormone on Key Developmental Features Revealed in a Series of Zebrafish Dyshormonogenesis Models.

Cells - 4 Aug 2021

Song Jia, Lu Yao, Cheng Xiaoxia, Shi Chuang, Lou Qiyong, Jin Xia, He Jiangyan, Zhai Gang, Yin Zhan

Abstract excerpt

The hypothalamic-pituitary-thyroid (HPT) axis regulates many critical features in vertebrates. Utilizing TALENs and CRISPR/Cas9 techniques, thyroid-stimulating hormone subunit beta a (tshba), thyroglobulin (tg), and solute carrier family 16 member 2 (slc16a2) mutant zebrafish lines were generated. Among the three mutants, the earliest time point for the significantly altered T3 contents was observed in tshba...

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Identifiers

PMID: 34440752
DOI: 10.3390/cells10081984
PMCID: PMC8391828

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