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Article

TSH receptor function is required for normal thyroid differentiation in zebrafish.

Molecular endocrinology (Baltimore, Md.) - 1 Sept 2011

Opitz Robert, Maquet Emilie, Zoenen Maxime, Dadhich Rajesh, Costagliola Sabine

Abstract excerpt

TSH is the primary physiological regulator of thyroid gland function. The effects of TSH on thyroid cells are mediated via activation of its membrane receptor [TSH receptor (TSHR)]. In this study, we examined functional thyroid differentiation in zebrafish and characterized the role of TSHR signaling during thyroid organogenesis. Cloning of a cDNA encoding zebrafish Tshr showed conservation of primary structure...

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Identifiers

PMID: 21737742
DOI: 10.1210/me.2011-0046
PMCID: PMC5417235

Genes

TSHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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