Article
The venous system of E14.5 mouse embryos-reference data and examples for diagnosing malformations in embryos with gene deletions.
Journal of anatomy - 1 Jan 2022
Geyer Stefan H, Maurer-Gesek Barbara, Reissig Lukas F, Rose Julia, Prin Fabrice, Wilson Robert, Galli Antonella, Tudor Catherine, White Jacqueline K, Mohun Timothy J, Weninger Wolfgang J
Abstract excerpt
Approximately one-third of randomly produced knockout mouse lines produce homozygous offspring, which fail to survive the perinatal period. The majority of these die around or after embryonic day (E)14.5, presumably from cardiovascular insufficiency. For diagnosing structural abnormalities underlying death and diseases and for researching gene function, the phenotype of these individuals has to be analysed. This...
Topics
- Animals
- Embryo, Mammalian
- Female
- Gene Deletion
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Phenotype
- Pregnancy