Probing Lanmodulin's Lanthanide Recognition via Sensitized Luminescence Yields a Platform for Quantification of Terbium in Acid Mine Drainage.

doi:10.1021/jacs.1c06360

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Article

Probing Lanmodulin's Lanthanide Recognition via Sensitized Luminescence Yields a Platform for Quantification of Terbium in Acid Mine Drainage.

Journal of the American Chemical Society - 8 Sept 2021

Featherston Emily R, Issertell Edward J, Cotruvo Joseph A

Abstract excerpt

Lanmodulin is the first natural, selective macrochelator for f elements-a protein that binds lanthanides with picomolar affinity at 3 EF hands, motifs that instead bind calcium in most other proteins. Here, we use sensitized terbium luminescence to probe the mechanism of lanthanide recognition by this protein as well as to develop a terbium-specific biosensor that can be applied directly in environmental samples....

Topics

Carrier Proteins
EF Hand Motifs
Luminescence
Luminescent Measurements
Mining
Mutation
Protein Binding
Terbium
Tryptophan
Wastewater

Source

Open in PubMed

Identifiers

PMID: 34432449
DOI: 10.1021/jacs.1c06360

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