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Article

Presenilin 1 Gene Mutation (M139V) in a German Family with Early-Onset Alzheimer's Disease: A Case Report.

Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists - 23 Feb 2022

Fuentes Manuel, Schipke Carola G, Freiesleben Silka Dawn, Klostermann Arne, Peters Oliver

Abstract excerpt

OBJECTIVE: This study describes a 44-year-old German male with early-onset Alzheimer's disease as a result of a M139V presenilin 1 mutation. The patient has at least seven affected family members, spanning at least four generations. METHOD: We performed a complete demographic, genetic, neuropsychological, neuropsychiatric, neuroradiological, and neuropathological characterizations of this patient. The findings...

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PMID: 34427587
DOI: 10.1093/arclin/acab070

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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