Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Germline SUCLG2 Variants in Patients With Pheochromocytoma and Paraganglioma

18 Aug 2021

Abstract excerpt

BACKGROUND: Pheochromocytoma and paraganglioma (PPGL) are neuroendocrine tumors with frequent mutations in genes linked to the tricarboxylic acid cycle. However, no pathogenic variant has been found to date in succinyl-CoA ligase (SUCL), an enzyme that provides substrate for succinate dehydrogenase (SDH; mitochondrial complex II [CII]), a known tumor suppressor in PPGL. METHODS: A cohort of 352 patients with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenal and Paraganglionic Tumors
Share to Neuroblastoma Research and Treatments
Share to Pituitary Gland Disorders and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34415331
DOI: 10.1093/jnci/djab158

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Germline SUCLG2 Variants in Patients With Pheochromocytoma and ParagangliomaPMID 34415331Read ↗

Germline DLST Variants Promote Epigenetic Modifications in Pheochromocytoma-Paraganglioma.Semantic proximity Read ↗

Genetic stratification of inherited and sporadic phaeochromocytoma and paraganglioma: implications for precision medicineSemantic proximity Read ↗

Back to Biochemistry: Evaluation for and Prognostic Significance of SDH Mutations in Paragangliomas and Pheochromocytomas.Semantic proximity Read ↗

Back to Biochemistry: Evaluation for and Prognostic Significance of SDH Mutations in Paragangliomas and Pheochromocytomas.Semantic proximity Read ↗

Hypothesis: Why Different Types of SDH Gene Variants Cause Divergent Tumor Phenotypes.Semantic proximity Read ↗

Expanding the phenotypic spectrum of Succinyl-CoA ligase deficiency through functional validation of a new SUCLG1 variant.Semantic proximity Read ↗

A study of succinate dehydrogenase deficient tumourigenesis : from functional assessment of variant pathogenicity to the discovery of new disease biomarkersSemantic proximity Read ↗

Germline FH Mutations Presenting With PheochromocytomaSemantic proximity Read ↗

Succinate-CoA ligase deficiency due to mutations in SUCLA2 and SUCLG1: phenotype and genotype correlations in 71 patients.Semantic proximity Read ↗

Somatic SDHA mutations in paragangliomas in siblings: Case report of 2 cases.Semantic proximity Read ↗

Succinate Dehydrogenase Mutations as Familial Pheochromocytoma Syndromes.Semantic proximity Read ↗

A review of the tumour spectrum of germline succinate dehydrogenase gene mutations: Beyond phaeochromocytoma and paraganglioma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.