Article
Succinate Dehydrogenase Mutations as Familial Pheochromocytoma Syndromes.
Surgical oncology clinics of North America - 1 Apr 2023
Lui Michael S, Clemente-Gutierrez Uriel, Skefos Catherine M, Perrier Nancy D
Abstract excerpt
It is recognized that a large portion of pheochromocytoma and paraganglioma cases will have an underlying germline mutation, supporting the recommendation for universal genetic testing in all patients with PPGLs. A mutation in succinate dehydrogenase subunit B is associated with increased rates of developing synchronous and/or metachronous metastatic disease. Patients identified with this mutation require...
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