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Article

The role of mitochondria dysfunction and hepatic senescence in NAFLD development and progression.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Oct 2021

Dabravolski Siarhei A, Bezsonov Evgeny E, Orekhov Alexander N

Abstract excerpt

Senescence is a crucial player in several metabolic disorders and chronic inflammatory diseases. Recent data prove the involvement of hepatocyte senescence in the development of NAFLD (non-alcoholic fatty liver disease). As the main energy and ROS (reactive oxygen species) producing organelle, mitochondria play the central role in accelerated senescence and diseases development. In this review, we focus on the...

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Identifiers

PMID: 34411916
DOI: 10.1016/j.biopha.2021.112041

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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