Article
Drosophila yellow-h encodes dopaminechrome tautomerase: A new enzyme in the eumelanin biosynthetic pathway.
Pigment cell & melanoma research - 1 Jan 2022
Barek Hanine, Zhao Heya, Heath Katerina, Veraksa Alexey, Sugumaran Manickam
Abstract excerpt
Melanin is a widely distributed phenolic pigment that is biosynthesized from tyrosine and its hydroxylated product, dopa, in all animals. However, recent studies reveal a significant deviation from this paradigm, as insects appear to use dopamine rather than dopa as the major precursor of melanin. This observation calls for a reconsideration of the insect melanogenic pathway. While phenoloxidases and laccases can...
Topics
- Animals
- Animals, Genetically Modified
- Cell Line
- Drosophila melanogaster
- Drosophila Proteins
- Indoles
- Intramolecular Oxidoreductases
- Melanins
- Mutation