Article
Polymorphisms at the IL17A and IL17RA Genes are Associated with Prognosis of Papillary Thyroid Carcinoma.
Archives of medical research - 1 Feb 2022
Bertol Bruna Cristina, Góes de Araújo Jéssica Nayara, de Carvalho Kleyton Thiago Costa, Gonzaga Dos Santos Marcos, Martelli-Palomino Gustavo, de Figueiredo Feitosa Nathalie Lobo, Maciel Léa Maria Zanini, Silbiger Vivian Nogueira, Lucena-Silva Norma, Freitas Janaina Cristiana de Oliveira Crispim, Donadi Eduardo Antônio
Abstract excerpt
BACKGROUND: Interleukin (IL)-17A has a dual role in tumor immunity, promotes anti-tumor responses and facilitates angiogenesis by interacting with IL-17 receptor A (IL-17RA). Although IL-17A has been associated with the pathogenesis of papillary thyroid carcinoma (PTC), the nucleotide variability at the IL17A and IL17RA genes is still poorly characterized. AIM: To assess the contribution of the IL17A (-197 G >A,...
Topics
- Case-Control Studies
- Genetic Predisposition to Disease
- Genotype
- Humans
- Interleukin-17
- Polymorphism, Single Nucleotide
- Prognosis
- Receptors, Interleukin-17
- Thyroid Cancer, Papillary