Association between IL-27 gene polymorphisms and risk of papillary thyroid carcinoma.

doi:10.2217/bmm-2016-0283

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Article

Association between IL-27 gene polymorphisms and risk of papillary thyroid carcinoma.

Biomarkers in medicine - 1 Feb 2017

Nie Xinwen, Yuan Fang, Chen Peng, Pu Yan, Zhu Jingqiang, Wang Yichao, Xiao Xue, Che Guanglu, Gao Linbo, Zhang Lin

Abstract excerpt

AIM: IL-27 has potent antitumor effects. We aimed to examine the contribution of single nucleotide polymorphisms in IL-27 to the risk of papillary thyroid carcinoma (PTC). MATERIALS & METHODS: IL-27 rs153109 and rs17855750 were analyzed in 496 PTC patients and 629 controls, using a polymerase chain reaction-restriction fragment length polymorphism method. RESULTS: The rs153109 AG and AG/GG genotypes were...

Topics

Adult
Alleles
Carcinoma, Papillary
Case-Control Studies
Female
Gene Frequency
Genetic Predisposition to Disease

Source

Open in PubMed

Identifiers

PMID: 27929666
DOI: 10.2217/bmm-2016-0283

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Humans

Interleukin-27

Male

Middle Aged

Odds Ratio

Polymerase Chain Reaction

Polymorphism, Single Nucleotide

Risk Factors

Thyroid Cancer, Papillary

Thyroid Neoplasms