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Prognostic Significance of Gene Signature of Tertiary Lymphoid Structures in Patients With Lung Adenocarcinoma

26 Jul 2021

Abstract excerpt

Background Lung adenocarcinoma (LUAD) is a highly mortal cancer. Tertiary lymphoid structures (TLS) are ectopic lymphoid organs with similar morphological and molecular characters to secondary lymphoid organ. The aim of this study is to investigate the prognostic effect of a gene signature associated with TLSs, including B-cell-specific genes. Methods Clinical data of 515 LUAD patients in the TGCA cohort were...

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PMID: 34381716
DOI: 10.3389/fonc.2021.693234

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