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Genomic properties and clinical outcomes associated with tertiary lymphoid structures in patients with breast cancer

19 Aug 2023

Abstract excerpt

Tertiary lymphoid structures (TLSs) play a crucial role in determining prognosis and response to immunotherapy in several solid malignancies. Nevertheless, the effect of TLS-associated gene signature based on The Cancer Genome Atlas (TCGA) cohort in patients with breast cancer (BRCA) remains controversial. Based on TCGA-BRCA dataset (n = 866), 9-gene was identified to construct an TLS signature and further...

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PMID: 37598257
DOI: 10.1038/s41598-023-40042-7

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