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Article

Dynamic Spatiotemporal Expression Changes in Connexins of the Developing Primate's Cochlea.

Genes - 16 Jul 2021

Hosoya Makoto, Fujioka Masato, Murayama Ayako Y, Ogawa Kaoru, Okano Hideyuki, Ozawa Hiroyuki

Abstract excerpt

Connexins are gap junction components that are essential for acquiring normal hearing ability. Up to 50% of congenital, autosomal-recessive, non-syndromic deafness can be attributed to variants in GJB2, the gene that encodes connexin 26. Gene therapies modifying the expression of connexins are a feasible treatment option for some patients with genetic hearing losses. However, the expression patterns of these...

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Identifiers

PMID: 34356098
DOI: 10.3390/genes12071082
PMCID: PMC8307058

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dynamic Spatiotemporal Expression Changes in Connexins of the Developing Primate's Cochlea.PMID 34356098Read ↗

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Diverse deafness mechanisms of connexin mutations revealed by studies using in vitro approaches and mouse models.Semantic proximity Read ↗

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