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Differentiation of human pluripotent stem cells into functional airway basal stem cells

20 Jul 2021

Abstract excerpt

Airway basal cells play an essential role in the maintenance of the airway epithelium. Here, we provide a detailed directed differentiation protocol to generate ‘‘induced basal cells (iBCs)'' from human pluripotent stem cells. iBCs recapitulate biological and functional properties of airway basal cells including mucociliary differentiation in vitro or in vivo in tracheal xenografts, facilitating the study of...

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PMID: 34355203
DOI: 10.1016/j.xpro.2021.100683

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