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Article

Single-cell phenotypes of peripheral blood immune cells in early and late stages of non-alcoholic fatty liver disease.

Clinical and molecular hepatology - 1 Apr 2023

Waller Kathryn Jane, Saihi Hajar, Li Wenhao, Brindley James Hallimond, De Jong Anja, Syn Wing-Kin, Bessant Conrad, Alazawi William

Abstract excerpt

BACKGROUND/AIMS: Immune and inflammatory cells respond to multiple pathological hits in the development of nonalcoholic steatohepatitis (NASH) and fibrosis. Relatively little is known about how their type and function change through the non-alcoholic fatty liver disease (NAFLD) spectrum. Here we used multi-dimensional mass cytometry and a tailored bioinformatic approach to study circulating immune cells sampled...

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Identifiers

PMID: 36727210
DOI: 10.3350/cmh.2022.0205
PMCID: PMC10121278

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