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Acute granulomatous interstitial nephritis in a patient with metastatic melanoma on targeted therapy with dabrafenib and trametinib-A case report.

Cancer reports (Hoboken, N.J.) - 1 Jul 2022

Krelle Anna, Mathai Vinod Kalapurackal, Kirkland Geoff, Nott Louise, Jose Matthew D, Whale Karen

Abstract excerpt

BACKGROUND: Combination molecular targeted therapy with dabrafenib plus trametinib has been shown to improve progression-free survival and overall survival in patients with BRAF V600 mutated unresectable or metastatic melanoma. In general, these agents are well tolerated. Kidney related adverse events are uncommon with only three case reports of acute interstitial nephritis and one case of a serious acute kidney...

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Identifiers

PMID: 34350734
DOI: 10.1002/cnr2.1520
PMCID: PMC9327652

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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