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Article

A case of karyomegalic interstitial nephritis without FAN1 mutations in the setting of brentuximab, ifosfamide, and carboplatin exposure.

BMC nephrology - 14 Nov 2024

Leong Matthew, Dai Tiane, Tong Lili, Nast Cynthia C

Abstract excerpt

BACKGROUND: Karyomegalic interstitial nephritis (KIN) is a rare renal diagnosis associated with both genetic and medication etiologies. The primary gene associated with KIN is the FAN1 gene which encodes a protein responsible for DNA interstrand repair. Common medication triggers of KIN are chemotherapeutic agents, especially those which disrupt DNA structure such as carboplatin. Despite overlap between these...

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Identifiers

PMID: 39543462
DOI: 10.1186/s12882-024-03689-6
PMCID: PMC11566923

Genes

KIN
FAN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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