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Clinical features of acute kidney injury in patients receiving dabrafenib and trametinib.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 25 Feb 2022

Seethapathy Harish, Lee Meghan D, Strohbehn Ian A, Efe Orhan, Rusibamayila Nifasha, Chute Donald F, Colvin Robert B, Rosales Ivy A, Fadden Riley M, Reynolds Kerry L, Sullivan Ryan J, Kaufman Howard L, Jhaveri Kenar D, Sise Meghan E

Abstract excerpt

BACKGROUND: Our objective was to characterize the incidence, risk factors and clinical features of acute kidney injury (AKI) in patients receiving dabrafenib and trametinib. METHODS: We performed a retrospective cohort study examining the kidney outcomes of patients in a large healthcare system who received dabrafenib/trametinib between 2010 and 2019. The primary outcome was AKI, defined as a 1.5-fold increase in...

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PMID: 33355659
DOI: 10.1093/ndt/gfaa372
PMCID: PMC8875461

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