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Article

The Raine syndrome protein FAM20C is a Golgi kinase that phosphorylates bio-mineralization proteins.

PloS one - 1 Jan 2012

Ishikawa Hiroyuki O, Xu Aiguo, Ogura Eri, Manning Gerard, Irvine Kenneth D

Abstract excerpt

Raine syndrome is caused by mutations in FAM20C, which had been reported to encode a secreted component of bone and teeth. We found that FAM20C encodes a Golgi-localized protein kinase, distantly related to the Golgi-localized kinase Four-jointed. Drosophila also encode a Golgi-localized protein kinase closely related to FAM20C. We show that FAM20C can phosphorylate secreted phosphoproteins, including both Casein...

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Identifiers

PMID: 22900076
DOI: 10.1371/journal.pone.0042988
PMCID: PMC3416761

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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