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Article

The efficacy of interferon-beta therapy in multiple sclerosis patients: investigation of the RORA gene as a predictive biomarker.

The pharmacogenomics journal - 1 Apr 2020

Ayatollahi Seyed Abdulmajid, Ghafouri-Fard Soudeh, Taheri Mohammad, Noroozi Rezvan

Abstract excerpt

Multiple sclerosis (MS) is an autoimmune disease characterized by inflammatory neuronal damages and consequent disabilities. Episodic relapses of the disease which lead to brain lesions and irreversible neurological dysfunctions could be decreased by the interferon-beta (IFN-β) therapy in most of the MS patients. However, the efficiency of the drug response is highly variable among patients and the precise...

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PMID: 31649263
DOI: 10.1038/s41397-019-0114-0

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