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Article

Disruption of MAP7D1 Gene Function Increases the Risk of Doxorubicin-Induced Cardiomyopathy and Heart Failure.

BioMed research international - 1 Jan 2021

Li Li-Ping, Zhong Jing, Li Mei-Hang, Sun Yuan-Chao, Niu Yu-Juan, Wu Chuan-Hong, Zhou Jian-Feng, Norton Nadine, Li Zhi-Qiang, Shi Yong-Yong, Xu Xiao-Lei, Ding Yong-He

Abstract excerpt

Doxorubicin is a cornerstone chemotherapeutic drug widely used to treat various cancers; its dose-dependent cardiomyopathy, however, is one of the leading causes of treatment-associated mortality in cancer survivors. Patients' threshold doses leading to doxorubicin-induced cardiomyopathy (DIC) and heart failure are highly variable, mostly due to genetic variations in individuals' genomes. However, genetic...

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Identifiers

PMID: 34327238
DOI: 10.1155/2021/8569921
PMCID: PMC8302367

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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