Article
Dissecting indirect genetic effects from peers in laboratory mice.
Genome biology - 26 Jul 2021
Baud Amelie, Casale Francesco Paolo, Barkley-Levenson Amanda M, Farhadi Nilgoun, Montillot Charlotte, Yalcin Binnaz, Nicod Jerome, Palmer Abraham A, Stegle Oliver
Abstract excerpt
BACKGROUND: The phenotype of an individual can be affected not only by the individual's own genotypes, known as direct genetic effects (DGE), but also by genotypes of interacting partners, indirect genetic effects (IGE). IGE have been detected using polygenic models in multiple species, including laboratory mice and humans. However, the underlying mechanisms remain largely unknown. Genome-wide association studies...
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