Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

New and distinct chronic wasting disease strains associated with cervid polymorphism at codon 116 of the Prnp gene.

PLoS pathogens - 1 Jul 2021

Hannaoui Samia, Triscott Elizabeth, Duque Velásquez Camilo, Chang Sheng Chun, Arifin Maria Immaculata, Zemlyankina Irina, Tang Xinli, Bollinger Trent, Wille Holger, McKenzie Debbie, Gilch Sabine

Abstract excerpt

Chronic wasting disease (CWD) is a prion disease affecting cervids. Polymorphisms in the prion protein gene can result in extended survival of CWD-infected animals. However, the impact of polymorphisms on cellular prion protein (PrPC) and prion properties is less understood. Previously, we characterized the effects of a polymorphism at codon 116 (A>G) of the white-tailed deer (WTD) prion protein and determined...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arvicolinae
Share to Cricetinae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mesocricetus

Share to Polymorphism, Single Nucleotide

Share to Prion Proteins

Share to Wasting Disease, Chronic

Source

Open in PubMed Open full text

Identifiers

PMID: 34310662
DOI: 10.1371/journal.ppat.1009795
PMCID: PMC8341689

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

New and distinct chronic wasting disease strains associated with cervid polymorphism at codon 116 of the Prnp gene.PMID 34310662Read ↗

Destabilizing polymorphism in cervid prion protein hydrophobic core determines prion conformation and conversion efficiency.Semantic proximity Read ↗

Deer Prion Proteins Modulate the Emergence and Adaptation of Chronic Wasting Disease Strains.Semantic proximity Read ↗

Chronic wasting disease (CWD) prion detection in blood from pre-symptomatic white-tailed deer harboring PRNP polymorphic variants.Semantic proximity Read ↗

Review on PRNP genetics and susceptibility to chronic wasting disease of Cervidae.Semantic proximity Read ↗

Odocoileus virginianus PRNP sequencing reveals AF (Q95G96/H95G96) advantage over AC (Q95G96/Q95S96) against chronic wasting disease.Semantic proximity Read ↗

Prion protein polymorphisms affect chronic wasting disease progression.Semantic proximity Read ↗

Prion protein polymorphisms in white-tailed deer influence susceptibility to chronic wasting disease.Semantic proximity Read ↗

Chronic wasting disease (CWD) susceptibility of several North American rodents that are sympatric with cervid CWD epidemics.Semantic proximity Read ↗

Prion strain mutation determined by prion protein conformational compatibility and primary structure.Semantic proximity Read ↗

Chronic wasting disease: an evolving prion disease of cervids.Semantic proximity Read ↗

Estimating relative CWD susceptibility and disease progression in farmed white-tailed deer with rare PRNP alleles.Semantic proximity Read ↗

Predicting the spread-risk potential of chronic wasting disease to sympatric ungulate speciesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.