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Article

Evolution of ibrutinib resistance in chronic lymphocytic leukemia (CLL).

Proceedings of the National Academy of Sciences of the United States of America - 23 Sept 2014

Komarova Natalia L, Burger Jan A, Wodarz Dominik

Abstract excerpt

The Bruton tyrosine kinase inhibitor (BTKi) ibrutinib is a new targeted therapy for patients with chronic lymphocytic leukemia (CLL). Ibrutinib is given orally on a continuous schedule and induces durable remissions in the majority of CLL patients. However, a small proportion of patients initially responds to the BTKi and then develops resistance. Estimating the frequency, timing, and individual risk of...

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Identifiers

PMID: 25201956
DOI: 10.1073/pnas.1409362111
PMCID: PMC4183279

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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