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Article

Somatotroph Tumors and the Epigenetic Status of the GNAS Locus.

International journal of molecular sciences - 15 Jul 2021

Romanet Pauline, Galluso Justine, Kamenicky Peter, Hage Mirella, Theodoropoulou Marily, Roche Catherine, Graillon Thomas, Etchevers Heather C, De Murat Daniel, Mougel Grégory, Figarella-Branger Dominique, Dufour Henry, Cuny Thomas, Assié Guillaume, Barlier Anne

Abstract excerpt

Forty percent of somatotroph tumors harbor recurrent activating GNAS mutations, historically called the gsp oncogene. In gsp-negative somatotroph tumors, GNAS expression itself is highly variable; those with GNAS overexpression most resemble phenotypically those carrying the gsp oncogene. GNAS is monoallelically expressed in the normal pituitary due to methylation-based imprinting. We hypothesize that changes in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

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Share to GTP-Binding Protein alpha Subunits, Gs

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Source

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Identifiers

PMID: 34299200
DOI: 10.3390/ijms22147570
PMCID: PMC8306130

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