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Article

SOX21 modulates SOX2-initiated differentiation of epithelial cells in the extrapulmonary airways

21 Jul 2021

Abstract excerpt

SOX2 expression levels are crucial for the balance between maintenance and differentiation of airway progenitor cells during development and regeneration. Here, we describe patterning of the mouse proximal airway epithelium by SOX21, which coincides with high levels of SOX2 during development. Airway progenitor cells in this SOX2+/SOX21+ zone show differentiation to basal cells, specifying cells for the...

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PMID: 34286693
DOI: 10.7554/elife.57325

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