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Article

Lymphatics in bone arise from pre-existing lymphatics.

Development (Cambridge, England) - 20 Apr 2020

Monroy Marco, McCarter Anna L, Hominick Devon, Cassidy Nina, Dellinger Michael T

Abstract excerpt

Bones do not normally have lymphatics. However, individuals with generalized lymphatic anomaly (GLA) or Gorham-Stout disease (GSD) develop ectopic lymphatics in bone. Despite growing interest in the development of tissue-specific lymphatics, the cellular origin of bone lymphatic endothelial cells (bLECs) is not known and the development of bone lymphatics has not been fully characterized. Here, we describe the...

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Identifiers

PMID: 32188632
DOI: 10.1242/dev.184291
PMCID: PMC7188445

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