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Article

Residue-specific binding mechanisms of PD-L1 to its monoclonal antibodies by computational alanine scanning.

Physical chemistry chemical physics : PCCP - 28 Jul 2021

Wen Wei, Huang Dading, Bao Jingxiao, Zhang John Z H

Abstract excerpt

Programmed cell death 1 receptor (PD-1) on the surface of T cells and its ligand 1 (PD-L1) are immune checkpoint proteins. Treating cancer patients with inhibitors blocking this checkpoint has significantly prolonged the survival rate of patients. In this study, we examined several monoclonal antibodies (mAbs) of PD-L1 and studied their detailed binding mechanism to PD-L1. An efficient computational alanine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34259259
DOI: 10.1039/d1cp01281a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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