Article
Tissue-specific expression of Cas9 has no impact on whole-body metabolism in four transgenic mouse lines.
Molecular metabolism - 1 Nov 2021
Bond Simon T, Zhuang Aowen, Yang Christine, Gould Eleanor A M, Sikora Tim, Liu Yingying, Fu Ying, Watt Kevin I, Tan Yanie, Kiriazis Helen, Lancaster Graeme I, Gregorevic Paul, Henstridge Darren C, McMullen Julie R, Meikle Peter J, Calkin Anna C, Drew Brian G
Abstract excerpt
OBJECTIVE: CRISPR/Cas9 technology has revolutionized gene editing and fast tracked our capacity to manipulate genes of interest for the benefit of both research and therapeutic applications. Whilst many advances have, and continue to be made in this area, perhaps the most utilized technology to date has been the generation of knockout cells, tissues and animals. The advantages of this technology are many fold,...
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