Article
Identification of simple arylfluorosulfates as potent agents against resistant bacteria.
Proceedings of the National Academy of Sciences of the United States of America - 13 Jul 2021
Zhang Jiong, Zhao Xiangxiang, Cappiello John R, Yang Yi, Cheng Yunfei, Liu Guang, Fang Wenjing, Luo Yinzhu, Zhang Yu, Dong Jiajia, Zhang Lixin, Sharpless K Barry
Abstract excerpt
Sulfur fluoride exchange (SuFEx), a next generation of click chemistry, opens an avenue for drug discovery. We report here the discovery and structure-activity relationship studies of a series of arylfluorosulfates, synthesized via SuFEx, as antibacterial agents. Arylfluorosulfates 3, 81, and 101 showed potency to overcome multidrug resistance and were not susceptible to the generation of resistance. They...
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