Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: identification of the cycloalkylcarboxylic acids.

doi:10.1021/jm200938f

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Article

Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: identification of the cycloalkylcarboxylic acids.

Journal of medicinal chemistry - 8 Dec 2011

LaMarche Matthew J, Leeds Jennifer A, Amaral Kerri, Brewer Jason T, Bushell Simon M, Dewhurst Janetta M, Dzink-Fox JoAnne, Gangl Eric, Goldovitz Julie, Jain Akash, Mullin Steve, Neckermann Georg, Osborne Colin, Palestrant Deborah, Patane Michael A, Rann Elin M, Sachdeva Meena, Shao Jian, Tiamfook Stacey, Whitehead Lewis, Yu Donghui

Abstract excerpt

4-Aminothiazolyl analogues of the antibiotic natural product GE2270 A (1) were designed, synthesized, and optimized for their activity against Gram positive bacterial infections. Optimization efforts focused on improving the physicochemical properties (e.g., aqueous solubility and chemical stability) of the 4-aminothiazolyl natural product template while improving the in vitro and in vivo antibacterial activity....

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PMID: 21999529
DOI: 10.1021/jm200938f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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