Article
Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency.
Immunity - 17 Jan 2017
Simoni Yannick, Fehlings Michael, Kløverpris Henrik N, McGovern Naomi, Koo Si-Lin, Loh Chiew Yee, Lim Shawn, Kurioka Ayako, Fergusson Joannah R, Tang Choong-Leong, Kam Ming Hian, Dennis Koh, Lim Tony Kiat Hon, Fui Alexander Chung Yaw, Hoong Chan Weng, Chan Jerry Kok Yen, Curotto de Lafaille Maria, Narayanan Sriram, Baig Sonia, Shabeer Muhammad, Toh Sue-Anne Ee Shiow, Tan Henry Kun Kiaang, Anicete Rosslyn, Tan Eng-Huat, Takano Angela, Klenerman Paul, Leslie Alasdair, Tan Daniel S W, Tan Iain Beehuat, Ginhoux Florent, Newell Evan W
Abstract excerpt
Animal models have highlighted the importance of innate lymphoid cells (ILCs) in multiple immune responses. However, technical limitations have hampered adequate characterization of ILCs in humans. Here, we used mass cytometry including a broad range of surface markers and transcription factors to accurately identify and profile ILCs across healthy and inflamed tissue types. High dimensional analysis allowed for...
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