Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Plasmodium falciparum finds the winning combination.

The Journal of biological chemistry - 1 Jan 2000

Hengge Alvan C

Abstract excerpt

After 3 years of laboratory drug pressure in the presence of a picomolar inhibitor, the parasite Plasmodium falciparum developed a combination strategy of gene amplification and mutation to regain viability. The mutation observed led to a dysfunctional enzyme, but new research reveals the clever mechanism behind its success. Not that we needed a reminder of nature's creativity in the time of a pandemic.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anopheles
Share to Drug Resistance
Share to Genes, Protozoan

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Plasmodium falciparum

Source

Open in PubMed Open full text

Identifiers

PMID: 34237898
DOI: 10.1016/j.jbc.2021.100526
PMCID: PMC8047455

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Plasmodium falciparum finds the winning combination.PMID 34237898Read ↗

Asexual Populations of the Human Malaria Parasite, Plasmodium falciparum, Use a Two-Step Genomic Strategy to Acquire Accurate, Beneficial DNA AmplificationsSemantic proximity Read ↗

A Research Agenda for Malaria Eradication: Basic Science and Enabling TechnologiesSemantic proximity Read ↗

Winning the arms race by improving drug discovery against mutating targets.Semantic proximity Read ↗

Mechanistic insights into dual-active liver and blood-stage antiplasmodials.Semantic proximity Read ↗

Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum.Semantic proximity Read ↗

In Vitro Resistance Selections for Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-binding Site and Altered GrowthSemantic proximity Read ↗

Uncovering the essential genes of the human malaria parasite Plasmodium falciparum by saturation mutagenesisSemantic proximity Read ↗

Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility.Semantic proximity Read ↗

Plasmodium falciparum culture: The benefits of shakingSemantic proximity Read ↗

Defining the biology component of the drug discovery strategy for malaria eradicationSemantic proximity Read ↗

Evolution of resistance in vitro reveals a novel mechanism of artemisinin activity in <i>Toxoplasma gondii</i>Semantic proximity Read ↗

Quinoxaline-based anti-schistosomal compounds have potent anti-plasmodial activitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.