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Diverse high-affinity DNA aptamers for wild-type and B.1.1.7 SARS-CoV-2 spike proteins from a pre-structured DNA library.

Nucleic acids research - 21 Jul 2021

Li Jiuxing, Zhang Zijie, Gu Jimmy, Stacey Hannah D, Ang Jann C, Capretta Alfredo, Filipe Carlos D M, Mossman Karen L, Balion Cynthia, Salena Bruno J, Yamamura Deborah, Soleymani Leyla, Miller Matthew S, Brennan John D, Li Yingfu

Abstract excerpt

We performed in vitro selection experiments to identify DNA aptamers for the S1 subunit of the SARS-CoV-2 spike protein (S1 protein). Using a pool of pre-structured random DNA sequences, we obtained over 100 candidate aptamers after 13 cycles of enrichment under progressively more stringent selection pressure. The top 10 sequences all exhibited strong binding to the S1 protein. Two aptamers, named MSA1 (Kd = 1.8...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34232998
DOI: 10.1093/nar/gkab574
PMCID: PMC8287928

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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