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Article

Diseases caused by mutations in the Na+/K+ pump α1 gene ATP1A1.

American journal of physiology. Cell physiology - 1 Aug 2021

Biondo Elisa D, Spontarelli Kerri, Ababioh Giovanna, Méndez Lois, Artigas Pablo

Abstract excerpt

Human cell survival requires function of the Na+/K+ pump; the heteromeric protein that hydrolyzes ATP to extrude Na+ and import K+ across the plasmalemma, thereby building and maintaining these ions' electrochemical gradients. Numerous dominant diseases caused by mutations in genes encoding for Na+/K+ pump catalytic (α) subunit isoforms highlight the importance of this protein. Here, we review literature...

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Identifiers

PMID: 34232746
DOI: 10.1152/ajpcell.00059.2021
PMCID: PMC8424680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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