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Article

REVA as A Well-curated Database for Human Expression-modulating Variants.

Genomics, proteomics & bioinformatics - 1 Aug 2021

Wang Yu, Shi Fang-Yuan, Liang Yu, Gao Ge

Abstract excerpt

More than 90% of disease- and trait-associated human variants are noncoding. By systematically screening multiple large-scale studies, we compiled REVA, a manually curated database for over 11.8 million experimentally tested noncoding variants with expression-modulating potentials. We provided 2424 functional annotations that could be used to pinpoint the plausible regulatory mechanism of these variants. We...

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PMID: 34224878
DOI: 10.1016/j.gpb.2021.06.001
PMCID: PMC9040024

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