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Article

Computational Assessment of the Expression-modulating Potential for Non-coding Variants.

Genomics, proteomics & bioinformatics - 1 Jun 2023

Shi Fang-Yuan, Wang Yu, Huang Dong, Liang Yu, Liang Nan, Chen Xiao-Wei, Gao Ge

Abstract excerpt

Large-scale genome-wide association studies (GWAS) and expression quantitative trait locus (eQTL) studies have identified multiple non-coding variants associated with genetic diseases by affecting gene expression. However, pinpointing causal variants effectively and efficiently remains a serious challenge. Here, we developed CARMEN, a novel algorithm to identify functional non-coding expression-modulating...

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Identifiers

PMID: 34890839
DOI: 10.1016/j.gpb.2021.10.003
PMCID: PMC10787178

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