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Article

Significance of PD1 Alternative Splicing in Celiac Disease as a Novel Source for Diagnostic and Therapeutic Target.

Frontiers in immunology - 1 Jan 2021

Ponce de León Candelaria, Lorite Pedro, López-Casado Miguel Ángel, Barro Francisco, Palomeque Teresa, Torres María Isabel

Abstract excerpt

Background: We have focused on the alteration of the PD-1/PD-L1 pathway in celiac disease and discussed the roles of the PD1 pathway in regulating the immune response. We explored the idea that the altered mRNA splicing process in key regulatory proteins could represent a novel source to identify diagnostic, prognostic, and therapeutic targets in celiac disease. Methods: We characterized the PD1 mRNA variants'...

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Identifiers

PMID: 34220824
DOI: 10.3389/fimmu.2021.678400
PMCID: PMC8242946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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