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Targeting PARP proteins in acute leukemia: DNA damage response inhibition and therapeutic strategies

22 Jan 2022

Abstract excerpt

The members of the Poly(ADP-ribose) polymerase (PARP) superfamily are involved in several biological processes and, in particular, in the DNA damage response (DDR). The most studied members, PARP1, PARP2 and PARP3, act as sensors of DNA damages, in order to activate different intracellular repair pathways, including single-strand repair, homologous recombination, conventional and alternative non-homologous end...

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PMID: 35065680
DOI: 10.1186/s13045-022-01228-0

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