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Article

Revisiting HBV resistance to entecavir with a phenotypic approach.

Antiviral research - 1 Sept 2020

Marlet Julien, Lier Clément, Roch Emmanuelle, Maugey Morgan, Moreau Alain, Combe Benjamin, Lefeuvre Sandrine, d'Alteroche Louis, Barbereau Didier, Causse Xavier, Bastides Frédéric, Bachelier Marie-Nadege, Brand Denys, Gaudy-Graffin Catherine

Abstract excerpt

Treatment adaptation after hepatitis B virus (HBV) treatment failure relies on genotypic resistance testing. However, the results of such tests are not always consistent with treatment response. These discrepancies may be due to differences in resistance levels between isolates with the same genotypic resistance testing profiles. We explored this hypothesis by investigating six cases of entecavir treatment...

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PMID: 32735901
DOI: 10.1016/j.antiviral.2020.104869

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