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Article

DNA Methylation of Human Choline Kinase Alpha Promoter-Associated CpG Islands in MCF-7 Cells.

Genes - 1 Jun 2021

Mohamed Sa'dom Siti Aisyah Faten, Raikundalia Sweta, Shamsuddin Shaharum, See Too Wei Cun, Few Ling Ling

Abstract excerpt

Choline kinase (CK) is the enzyme catalyzing the first reaction in CDP-choline pathway for the biosynthesis of phosphatidylcholine. Higher expression of the α isozyme of CK has been implicated in carcinogenesis, and inhibition or downregulation of CKα (CHKA) is a promising anticancer approach. This study aimed to investigate the regulation of CKα expression by DNA methylation of the CpG islands found on the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34205960
DOI: 10.3390/genes12060853
PMCID: PMC8229565

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