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Mitochondrial DNA Copy Number and Developmental Origins of Health and Disease (DOHaD)

21 Jun 2021

Abstract excerpt

Mitochondrial dysfunction is known to contribute to mitochondrial diseases, as well as to a variety of aging-based pathologies. Mitochondria have their own genomes (mitochondrial DNA (mtDNA)) and the abnormalities, such as point mutations, deletions, and copy number variations, are involved in mitochondrial dysfunction. In recent years, several epidemiological studies and animal experiments have supported the...

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PMID: 34205712
DOI: 10.3390/ijms22126634

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