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Article

The paternal toolbox for embryo development and health

28 Jun 2021

Abstract excerpt

The sperm is essential for reconstitution of embryonic diploidy and highly specialized developmental functions. Immediately after gamete fusion, the sperm-borne PLC-zeta triggers activation, generating intracellular free Ca2+ oscillations. Mutations in the PLC-zeta encoding gene are associated with the absence of this factor in mature sperm and inability to achieve fertilization. Sperm play also a role in the...

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PMID: 34191013
DOI: 10.1093/molehr/gaab042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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