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Article

Restoration of the molecular clock is tumor suppressive in neuroblastoma

28 Jun 2021

Abstract excerpt

MYCN activation is a hallmark of advanced neuroblastoma (NB) and a known master regulator of metabolic reprogramming, favoring NB adaptation to its microenvironment. We found that the expression of the main regulators of the molecular clock loops is profoundly disrupted in MYCN-amplified NB patients, and this disruption independently predicts poor clinical outcome. MYCN induces the expression of clock repressors...

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PMID: 34183658
DOI: 10.1038/s41467-021-24196-4

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