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Article

An L0 Regularization Method for Imaging Genetics and Whole Genome Association Analysis on Alzheimer's Disease.

IEEE journal of biomedical and health informatics - 1 Sept 2021

Li Xiong, Lin Yangkai, Meng Xu, Qiu Yangping, Hu Bo

Abstract excerpt

Although the neuroimaging measures build a bridge between genetic variants and disease phenotypes, an assessment of single nucleotide variants changes in brain structure and their clinically influence on the progression of Alzheimer's disease remain largely preliminary. Note that each variant has very weak correlation signal to neuroimaging measures or Alzheimer's disease phenotypes. Therefore, traditional sparse...

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PMID: 34181562
DOI: 10.1109/JBHI.2021.3093027

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