Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Non–Cell Autonomous Epileptogenesis in Focal Cortical Dysplasia

28 Jun 2021

Abstract excerpt

OBJECTIVE: Low-level somatic mosaicism in the brain has been shown to be a major genetic cause of intractable focal epilepsy. However, how a relatively few mutation-carrying neurons are able to induce epileptogenesis at the local network level remains poorly understood. METHODS: To probe the origin of epileptogenesis, we measured the excitability of neurons with MTOR mutation and nearby nonmutated neurons...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epilepsy research and treatment
Share to Neuroscience and Neuropharmacology Research
Share to Tuberous Sclerosis Complex Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34180075
DOI: 10.1002/ana.26149

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Non–Cell Autonomous Epileptogenesis in Focal Cortical DysplasiaPMID 34180075Read ↗

Threshold of somatic mosaicism leading to brain dysfunction with focal epilepsy.Semantic proximity Read ↗

Pathogenic MTOR somatic variant causing focal cortical dysplasia drives hyperexcitability <i>via</i> overactivation of neuronal GluN2C NMDA receptorsSemantic proximity Read ↗

Threshold of somatic mosaicism disrupting the brain functionSemantic proximity Read ↗

Cortical Dysplasia and the mTOR Pathway: How the Study of Human Brain Tissue Has Led to Insights into Epileptogenesis.Semantic proximity Read ↗

The genetics of focal epilepsies.Semantic proximity Read ↗

Brain somatic mutations in MTOR leading to focal cortical dysplasia.Semantic proximity Read ↗

Genetic models of focal epilepsies.Semantic proximity Read ↗

Single-cell genotyping and transcriptomic profiling in focal cortical dysplasiaSemantic proximity Read ↗

New developments in understanding focal cortical malformations.Semantic proximity Read ↗

BRAFV600E expression in neural progenitors results in a hyperexcitable phenotype in neocortical pyramidal neurons.Semantic proximity Read ↗

Anti-seizure Gene Therapy for Focal Cortical DysplasiaSemantic proximity Read ↗

Single-cell genotyping and transcriptomic profiling of mosaic focal cortical dysplasia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.