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Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons

26 Jun 2021

Abstract excerpt

Induced pluripotent stem cells (iPSCs) and their differentiated neurons (iPSC-neurons) are a widely used cellular model in the research of the central nervous system. However, it is unknown how well they capture age-associated processes, particularly given that pluripotent cells are only present during the earliest stages of mammalian development. Epigenetic clocks utilize coordinated age-associated changes in...

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PMID: 34174924
DOI: 10.1186/s13041-021-00810-w

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