Article
Anti-Double-Stranded DNA Antibodies Recognize DNA Presented on HLA Class II Molecules of Systemic Lupus Erythematosus Risk Alleles.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Jan 2022
Tsuji Hideaki, Ohmura Koichiro, Jin Hui, Naito Ryota, Arase Noriko, Kohyama Masako, Suenaga Tadahiro, Sakakibara Shuhei, Kochi Yuta, Okada Yukinori, Yamamoto Kazuhiko, Kikutani Hitoshi, Morinobu Akio, Mimori Tsuneyo, Arase Hisashi
Abstract excerpt
OBJECTIVE: Specific HLA class II alleles are associated with susceptibility to systemic lupus erythematosus (SLE). The role of HLA class II molecules in SLE pathogenesis remains unclear, although anti-DNA antibodies are specific to SLE and correlate with disease activity. We previously demonstrated that misfolded proteins bound to HLA class II molecules are specific targets for the autoantibodies produced in...
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